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			<database name="LMW Allergens" path="D:\Bibliografia Generale\LMW Allergens">LMW Allergens</database>
			<source-app name="Reference Manager 11.0" version="11.0.1.1709">Reference Manager 11.0</source-app>
			<rec-number>38838</rec-number>
			<ref-type name="Journal">17</ref-type>
			<contributors>
				<authors>
					<author>
						<style face="normal" font="default">Hendaus,M.A.</style>
					</author>
					<author>
						<style face="normal" font="default"> Jomha,F.A.</style>
					</author>
					<author>
						<style face="normal" font="default"> Alhammadi,A.H.</style>
					</author>
				</authors>
			</contributors>
			<auth-address>
				<style face="normal" font="default">Department of Pediatrics, Section of Academic General Pediatrics, Hamad Medical Corporation, Doha, Qatar; Department of Clinical Pediatrics, Weill Cornell Medical College in Qatar, Doha, Qatar</style>
			</auth-address>
			<titles>
				<title>
					<style face="normal" font="default">Is ketamine a lifesaving agent in childhood acute severe asthma?</style>
				</title>
				<secondary-title>
					<style face="normal" font="default">Ther Clin Risk Manag</style>
				</secondary-title>
			</titles>
			<periodical>
				<abbr-1>
					<style face="normal" font="System">Ther Clin Risk Manag</style>
				</abbr-1>
			</periodical>
			<pages end="279" start="273">273-279</pages>
			<volume>
				<style face="normal" font="default">12</style>
			</volume>
			<reprint-status status="no-file"/>
			<keywords>
				<keyword>
					<style face="normal" font="default">asthma</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> asthma exacerbation</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Asthma exacerbations</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Asthma in children</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> childhood</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Childhood asthma</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Children</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Clinical</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Databases</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> drug</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Emergencies</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> emergency</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Exacerbation</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> exacerbations</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Intubation</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> ITS</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Literature</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> management</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Medical</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Medline</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> pediatric</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Pediatricians</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Pediatrics</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Qatar</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Review</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Risk</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Safety</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> school</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> severe</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> severe asthma</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Side effect</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> side effects</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Term</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> therapy</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> use</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> Ventilation</style>
				</keyword>
				<keyword>
					<style face="normal" font="default"> WAS</style>
				</keyword>
			</keywords>
			<dates>
				<year Day="0" Month="0" Year="2016">2016</year>
			</dates>
			<abstract>
				<style face="normal" font="default">Children with acute severe asthma exacerbation are at risk of developing respiratory failure. Moreover, conventional aggressive management might be futile in acute severe asthma requiring intubation and invasive ventilation. The aim of this review is to detail evidence on the use of ketamine in childhood asthma exacerbations. A search of the MEDLINE, EMBASE, and Cochrane databases was performed, using different combinations of the following terms: ketamine, asthma, use, exacerbation, and childhood. In addition, we searched the references of the identified articles for additional articles. We then reviewed titles and included studies that were relevant to the topic of interest. Finally, the search was limited to studies published in English and Spanish from 1918 to June 2015. Due to the scarcity in the literature, we included all published articles. The literature reports conflicting results of ketamine use for acute severe asthma in children. Taking into consideration the relatively good safety profile of the drug, ketamine might be a reasonable option in the management of acute severe asthma in children who fail to respond to standard therapy. Furthermore, pediatricians and pediatric emergency clinicians administering ketamine should be knowledgeable about the unique actions of this drug and its potential side effects</style>
			</abstract>
			<notes>
				<style face="normal" font="default">DA - 20160309IS - 1176-6336 (Print)IS - 1176-6336 (Linking)LA - engPT - Journal ArticlePT - ReviewCO - Qatar -CO - Lebanon -</style>
			</notes>
			<work-type>
				<style face="normal" font="default">10.2147/TCRM.S100389</style>
			</work-type>
			<urls>
				<web-urls>
					<url has-ut="yes" ppv-app="PM" ppv-ref="yes" ppv-ut="26955277">PM:26955277</url>
				</web-urls>
				<pdf-urls>
					<url ppv-ref="no">C:\A&amp;H LMW Papers\Ther Clin Risk Manag\2016-12-273-9.pdf</url>
				</pdf-urls>
				<text-urls>
					<url ppv-ref="no">F:\A&amp;H LMW Papers\Ther Clin Risk Manag\2016-12-273-9.pdf</url>
				</text-urls>
			</urls>
			<custom2>
				<style face="normal" font="default">20160309, Hendaus MA</style>
			</custom2>
			<misc3>
				<style face="normal" font="default">10.2147/TCRM.S100389</style>
			</misc3>
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