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      <database name="HMW 2 Allergens" path="D:\Bibliografia Generale\HMW 2 Allergens">HMW 2 Allergens</database>
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      <rec-number>70439</rec-number>
      <ref-type name="Journal">17</ref-type>
      <contributors>
        <authors>
          <author>
            <style face="normal" font="Arial">Chiu,C.Y.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Huang,Y.L.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Tsai,M.H.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Tu,Y.L.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Hua,M.C.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Yao,T.C.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Yeh,K.W.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Huang,J.L.</style>
          </author>
        </authors>
      </contributors>
      <auth-address>
        <style face="normal" font="Arial">Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan</style>
      </auth-address>
      <titles>
        <title>
          <style face="normal" font="Arial">Sensitization to Food and Inhalant Allergens in Relation to Atopic Diseases in Early Childhood: A Birth Cohort Study</style>
        </title>
        <secondary-title>
          <style face="normal" font="Arial">PLoS One</style>
        </secondary-title>
      </titles>
      <periodical>
        <abbr-1>
          <style face="normal" font="Arial">PLoS One</style>
        </abbr-1>
      </periodical>
      <pages end="" start="e102809">e102809-</pages>
      <volume>
        <style face="normal" font="Arial">9</style>
      </volume>
      <number>
        <style face="normal" font="Arial">7</style>
      </number>
      <reprint-status status="in-file"/>
      <keywords>
        <keyword>
          <style face="normal" font="Arial">1--Allergeni Nativi</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> age</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Aged</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Allergen-sensitization</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> allergen</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> allergen sensitization</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Allergens</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Allergic</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Allergic disease</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> allergic diseases</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Allergic respiratory diseases</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Allergies</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Allergy</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Antibodies</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Antibody</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> association</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Asthma</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> atopic</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> atopic disease</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> atopic diseases</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> birth</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> birth cohort</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> birth cohort studies</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> childhood</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Children</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Cohort</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Cohort Studies</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> cohort study</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Development</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Disease</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> early childhood</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Electronic</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Follow-up</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> follow up</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Food</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Food allergen</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> IgE</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> IgE antibodies</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> IgE antibody</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Inhalant</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> inhalant allergen</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Inhalant allergens</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Interpretation</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> methods</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> patterns</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> pediatric</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Pediatrics</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Prediction</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Prevalence</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Production</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Respiratory disease</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Respiratory diseases</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Risk</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> sensitization</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Serum</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> serum IgE</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> serum IgE levels</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Specific IgE</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Specific IgE antibodies</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> susceptibility</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Taiwan</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> total IgE</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> total serum IgE</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> WAS</style>
        </keyword>
      </keywords>
      <dates>
        <year Day="0" Month="0" Year="2014">2014</year>
      </dates>
      <abstract>
        <style face="normal" font="Arial">OBJECTIVES: A correct interpretation of sensitization to common allergens is critical in determining susceptibility to allergic diseases. The aim of this study was to investigate the patterns of sensitization to food and inhalant allergens, and their relation to the development of atopic diseases in early childhood. METHODS: Children aged 0 through 4 years from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Specific IgE antibody against food and inhalant allergens were measured and their association between total serum IgE levels and atopic diseases were assessed. RESULTS: A total of 182 children were regular followed up at clinics for a four-year follow-up period. The prevalence of food allergen sensitization increased markedly after 6 months of age, reaching up to 47% at 1.5 years of age and then declined significantly to 10% in parallel with a considerable increase in the prevalence of sensitization to inhalant allergens up to 25% at age 4. Food allergen sensitization appeared to be mainly associated with the elevation of serum total IgE levels before age 2. A combined sensitization to food and inhalant allergens had an additive effect on serum IgE levels after age 2, and was significantly associated with the risk of developing atopic diseases at age 4. CONCLUSIONS: Sensitization to food occurs early in life, in parallel with the rising prevalence of sensitization to inhalant allergens at older age. A combined sensitization to food and inhalant allergens not only has an additive increase in serum IgE antibody production but also increases the risk of developing allergic respiratory diseases in early childhood</style>
      </abstract>
      <notes>
        <style face="normal" font="Arial">DA - 20140717IS - 1932-6203 (Electronic)IS - 1932-6203 (Linking)LA - ENGPT - JOURNAL ARTICLECO - Taiwan -</style>
      </notes>
      <work-type>
        <style face="normal" font="Arial">10.1371/journal.pone.0102809</style>
      </work-type>
      <urls>
        <web-urls>
          <url has-ut="yes" ppv-app="PM" ppv-ref="yes" ppv-ut="25033453">PM:25033453</url>
        </web-urls>
        <pdf-urls>
          <url ppv-ref="no">C:\A&amp;H HMW Papers\PLoS One\2014-9-e102809.pdf</url>
        </pdf-urls>
        <text-urls>
          <url ppv-ref="no">F:\A&amp;H HMW Papers\PLoS One\2014-9-e102809.pdf</url>
        </text-urls>
      </urls>
      <custom1>
        <style face="normal" font="Arial">3D</style>
      </custom1>
      <custom2>
        <style face="normal" font="Arial">20140717, Chiu CY</style>
      </custom2>
      <misc3>
        <style face="normal" font="Arial">10.1371/journal.pone.0102809</style>
      </misc3>
    </record>
    <record>
      <database name="HMW 2 Allergens" path="D:\Bibliografia Generale\HMW 2 Allergens">HMW 2 Allergens</database>
      <source-app name="Reference Manager 11.0" version="11.0.1.1709">Reference Manager 11.0</source-app>
      <rec-number>80822</rec-number>
      <ref-type name="Journal">17</ref-type>
      <contributors>
        <authors>
          <author>
            <style face="normal" font="Arial">Hon,K.L.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Tsang,Y.C.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Pong,N.H.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Leung,T.F.</style>
          </author>
          <author>
            <style face="normal" font="Arial"> Ip,M.</style>
          </author>
        </authors>
      </contributors>
      <auth-address>
        <style face="normal" font="Arial">Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China</style>
      </auth-address>
      <titles>
        <title>
          <style face="normal" font="Arial">Exploring Staphylococcus epidermidis in atopic eczema: friend or foe?</style>
        </title>
        <secondary-title>
          <style face="normal" font="Arial">Clin Exp Dermatol</style>
        </secondary-title>
      </titles>
      <periodical>
        <abbr-1>
          <style face="normal" font="Arial">Clin Exp Dermatol</style>
        </abbr-1>
      </periodical>
      <pages end="663" start="659">659-663</pages>
      <volume>
        <style face="normal" font="Arial">41</style>
      </volume>
      <number>
        <style face="normal" font="Arial">6</style>
      </number>
      <reprint-status status="no-file"/>
      <keywords>
        <keyword>
          <style face="normal" font="Arial">Aged</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Antihistamine</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> area</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> association</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> associations</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> atopic</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Atopic dermatitis</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> atopic eczema</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> childhood</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> China</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Chinese</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Clinical</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Culture</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Dermatitis</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Disease</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Eczema</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Electronic</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> frequency</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Growth</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Hong Kong</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Logistic regression</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> methods</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> microbiota</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> objective</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> objective SCORAD</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Odds Ratio</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Or</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> oral</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> paediatric</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> paediatrics</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> pathophysiology</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Patients</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> QOL</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> quality</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Quality of Life</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Quality-of-life</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Role</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> SCORAD</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Score</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Scoring</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> severe</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> severity</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Skin</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Staphylococcus</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Staphylococcus aureus</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Staphylococcus epidermidis</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> TEWL</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> transepidermal water loss</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Universities</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Wales</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> WAS</style>
        </keyword>
        <keyword>
          <style face="normal" font="Arial"> Water</style>
        </keyword>
      </keywords>
      <dates>
        <year Day="0" Month="8" Year="2016">2016/8</year>
      </dates>
      <abstract>
        <style face="normal" font="Arial">BACKGROUND: Staphylococcus aureus (SA) colonization/infection is important in the pathophysiology of childhood atopic dermatitis (AD), but the role of Staphylococcus epidermidis (SE) is unknown. AIM: To evaluate if SE co-infects with SA and is associated with more severe disease. METHODS: Associations between bacteriological culture results of skin swabs (taken from the most severely affected area and at the antecubital fossa) and SCORing Atopic Dermatitis (SCORAD) score, skin hydration, transepidermal water loss (TEWL) and quality of life (QoL) were evaluated. RESULTS: In 100 consecutive patients with AD (aged 12.4 +/- 4.8 years), SE was present in 28% and 32% of the swabs taken from the most severe area and the flexural area (antecubital fossa), respectively, whereas SA was present in 69% and 55%, respectively. Binomial logistic regression showed that SE was inversely associated with SA growth in the most severely affected skin site [adjusted odds ratio (aOR) = 0.42, 95% CI 0.22-0.81; P = 0.01], frequency of emollient usage (aOR = 0.50, 95% CI 0.29-0.87; P = 0.01) and frequency of oral antihistamine usage (aOR = 0.81, 95% CI 0.65-0.10, P &lt; 0.05), but positively associated with objective SCORAD (aOR = 1.04, 95% CI 1.00-1.02; P &lt; 0.05). SE in the antecubital fossa was not associated with SA growth, disease severity, QoL or any clinical parameters. CONCLUSIONS: SE may not be just a commensal bystander in the skin microbiota. The organism amensalistically displaces SA and is associated with more severe disease</style>
      </abstract>
      <notes>
        <style face="normal" font="Arial">DA - 20160715IS - 1365-2230 (Electronic)IS - 0307-6938 (Linking)LA - engPT - Journal ArticleSB - IMCO - Hong Kong -</style>
      </notes>
      <work-type>
        <style face="normal" font="Arial">10.1111/ced.12866</style>
      </work-type>
      <urls>
        <web-urls>
          <url has-ut="yes" ppv-app="PM" ppv-ref="yes" ppv-ut="27416972">PM:27416972</url>
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        <pdf-urls>
          <url ppv-ref="no">C:\A&amp;H HMW Papers\Clin Exp Dermatol\2016-41-659-63.pdf</url>
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          <url ppv-ref="no">F:\A&amp;H HMW Papers\Clin Exp Dermatol\2016-41-659-63.pdf</url>
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      <custom2>
        <style face="normal" font="Arial">20160715, Hon KL</style>
      </custom2>
      <misc3>
        <style face="normal" font="Arial">10.1111/ced.12866</style>
      </misc3>
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