<?xml version="1.0" encoding="UTF-8" standalone="no" ?><xml><records><record><database name="vuoto - Copia" path="F:\vuoto - Copia">vuoto - Copia</database><source-app name="Reference Manager 11.0" version="11.0.0.359">Reference Manager 11.0</source-app><rec-number>3</rec-number><ref-type name="Journal">1</ref-type><contributors><authors><author><style face="normal" font="default">Nemet,S</style></author><author><style face="normal" font="default"> Asher,I</style></author><author><style face="normal" font="default"> Yoles,I</style></author><author><style face="normal" font="default"> Baevsky,T</style></author><author><style face="normal" font="default"> Sthoeger,Z</style></author></authors></contributors><titles><title><style face="normal" font="default">Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder</style></title><secondary-title><style face="normal" font="default">Pediatr Allergy Immunol</style></secondary-title></titles><periodical><abbr-1><style face="normal" font="System">Pediatr Allergy Immunol</style></abbr-1></periodical><pages end="" start="">-</pages><volume><style face="normal" font="default">33</style></volume><number><style face="normal" font="default">6</style></number><reprint-status status="no-file"/><keywords><keyword><style face="normal" font="default">ADHD</style></keyword><keyword><style face="normal" font="default"> allergy</style></keyword><keyword><style face="normal" font="default"> ASD</style></keyword><keyword><style face="normal" font="default"> asthma</style></keyword><keyword><style face="normal" font="default"> children</style></keyword><keyword><style face="normal" font="default"> gender</style></keyword><keyword><style face="normal" font="default"> pediatric allergic disorders</style></keyword><keyword><style face="normal" font="default"> risk factor</style></keyword><keyword><style face="normal" font="default"> PMID</style></keyword></keywords><dates><year Day="1" Month="6" Year="2022">2022/6/1</year><pub-dates><date Day="27" Month="6" Year="2022">2022/6/27</date></pub-dates></dates><publisher><style face="normal" font="default">John Wiley &amp; Sons, Ltd</style></publisher><isbn><style face="normal" font="default">0905-6157</style></isbn><abstract><style face="normal" font="default">BackgroundPrevious studies reported controversial results regarding the association between allergic disorders and attention deficit hyperactivity disorder (ADHD)/autism spectrum disorder (ASD). The aim of this article was to investigate whether allergic disorders are associated with ADHD/ASD in a large cohort of pediatric patients.MethodsA retrospective study using the pediatric (0-18 year) database (ICD-9-CM codes) of Clalit Health Services during the years (2000-2018). Diagnosis of all disorders was made by specialist physicians.ResultsA total of 117 022 consecutive non-selective allergic children diagnosed with one or more allergic disorder (asthma, rhinitis, conjunctivitis, skin, food, or drug allergy) and 116 968 non-allergic children were enrolled to our study. The mean follow-up period was 11 ± 6 years. The presence of allergic disorders in early childhood (mean age of allergic diagnosis 4.5 ± 4.3 years) in boys as well as in girls significantly increased the risk to develop ADHD (O.R 2.45, CI 2.39-2.51; p &lt; .0001), ASD (O.R 1.17, CI 1.08-1.27; p &lt; .0001), or both ADHD + ASD (O.R 1.5, CI 1.35-1.79; p &lt; .0001). Children with more than one allergic comorbidity revealed a much higher risk. In a multivariable analysis (adjusted for age at study entry, number of yearly visits, and gender), the risk of allergic children to develop ADHD and ADHD + ASD, but not ASD alone, remained significantly higher.ConclusionAllergic disorder in early childhood significantly increased the risk to develop ADHD, and to a less extend ASD, in later life.</style></abstract><work-type><style face="normal" font="default">10.1111/pai.13819</style></work-type><urls><web-urls><url ppv-ref="no">https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13819</url></web-urls></urls><misc3><style face="normal" font="default">10.1111/pai.13819</style></misc3></record></records></xml>
